Evidence base


The objectives of WG7 are to critically examine the evidence base in support of the selected medicine for its

specified use and to determine whether if and how off-label use is addressed in the literature.

Key research questions:

1. What is the evidence base for the use of each of the selected medicines?

2. What is the epidemiological evidence underpinning disease priority (and/or GBD)?

3. What is the evidence of unmet need?